CTGLab

Our lab

CTGLab’s research activities focus on the development of computational solutions and models to transform molecular and clinical experimental data into relevant information for clinical decision-making in the field of Precision Medicine. The approach, as the team, is multidisciplinary combining mathematics, statistics and computer science to dissect the complexity of biological and medical data.

Main interests rely on:
• the development of computational methods for the identification and characterization of germline and somatic structural variants, such as DNA copy-number alteration
• the investigation of the functional impact of non-coding copy-number variants in neurodevelopmental disorders
• the study of patient-specific tumor heterogeneity by combining multi-omics and clinical data to identify novel patient subgroups for tailored therapy and monitoring
• the investigation of cancer-associated molecular mechanisms, in particular microRNAs and their regulatory networks
• the identification of non-invasive biomarkers for diagnostics, therapeutic monitoring and drug resistance